Meredith Grey è una giovane ragazza che, dopo la laurea in medicina, riesce ad entrare nel gruppo di tirocinanti di chirurgia del Seattle Grace Hospital. Si trasferisce così a Seattle, nella vecchia casa appartenuta alla madre. Qui si trova a condividere la nuova esperienza insieme ad un gruppo di giovani coetanei, tutti alle prese con i più svariati problemi, sentimentali e non. Meredith è figlia di Ellis Grey, una dottoressa di fama mondiale specialista in chirurgia generale, cosa che le fa sentire molto il peso del suo cognome
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